شیوع کم کاری مادرزادی تیروئید در نوزادان غربالگری شده ارجاعی به مرکز بهداشتی درمانی شهید قدسی شهر مشهد

Background and Aim: Congenital hypothyroidism is the most common metabolic disease and endocrine disorder in children and a major cause of preventable mental retardation, which can be prevented only by early diagnosis and treatment. This study aimed to determine the prevalence and associated factors of congenital hypothyroidism in newborns referred to shahid Ghodsi Health Center in Mashhad. Materials and Methods: This cross-sectional study was conducted in first six months of 2015 by 4484 newborn referred to shahid Ghodsi health center for the congenital hypothyroidism screening. Data were collected from the screening forms and were analyzed by two-sample T-test, analysis of variance, Chi-square and Fisher's exact tests and SPSS 21 software used. In all tests the significance level was 5 percent. Results: Of 4484 screened neonates, 51% and 48% newborns were male and female respectively. Recall rate was estimated to be 2.6% and prevalence of the disease was 1 in 370 neonates. Our study was shown that hypothyroidism had Significant statistical correlation with weight, type of nutrition, primary and serum TSH levels. Conclusion: Due to the high prevalence of congenital hypothyroidism in Mashhad, which is equal the prevalence of Iran and significantly higher than the values of the world, To identify factors associated with the disease, more widespread and comprehensive research is necessary As well as a more coherent planning to design appropriate interventions in order to prevent the disease.